Only you will know if you should go on holiday and leave Toby, is someone coming in to look after him in your home? if so, then I wouldn't worry too much, as he will cope fine in his own home, he will gradually get used to the layout of the house and will manage fine, as long as no one changes it.
Don't panic too much. dogs cope much better than we do with things, and he will soon get used to everything, as long as you all talk to him as normal and make things easy for him to get around the house and to find his water, food, bed, etc.